Here Are the 55 US AI Startups That Raised $100M or More in 2025

The pace of the AI sector showed little sign of easing in 2025. Although the number of companies securing individual funding rounds of more than $1 billion declined, the year still stood out for another reason: a growing share of startups raised multiple large rounds. In fact, four companies — with Anthropic alone closing two rounds above the $1 billion mark — joined that category, compared with eight companies that raised multiple rounds in 2024.

The question now is how 2026 will stack up. Early signals suggest another robust year may be taking shape. Elon Musk’s xAI revealed a massive $20 billion Series E round. At the same time, Sam Altman’s brain–computer interface startup, Merge Labs, announced a $250 million seed round led by OpenAI within the first weeks of the year. While it’s still very early, these openings point to continued momentum. We’ll be tracking closely to see whether that pace holds.

Below is a comprehensive list of U.S.-based AI companies that raised at least $100 million during the past year.

December

• Austin, Texas-based Mythic, a company focused on power-efficient AI compute, secured $125 million in a venture round led by DCVC. The funding was announced on December 17 and included participation from SoftBank, NEA, Linse Capital, and other investors.
• Chai Discovery revealed a $130 million Series B round on December 15. The biotech-focused AI company, which develops models for drug discovery, was valued at $1.2 billion. Oak HC/FT and General Catalyst co-led the round.
• Generative media platform Fal announced its third funding round of 2025 on December 9. The $140 million Series D round was led by Sequoia and valued the company at more than $4.5 billion.
• Unconventional AI disclosed a massive $475 million seed round on December 8. The round was led by Lightspeed Venture Partners and Andreessen Horowitz, valuing the one-year-old startup — which is reimagining the foundations of computing for the AI era — at nearly $4.5 billion.
• Boston-based 7AI, a company building cybersecurity AI agents, raised $130 million in a Series A round announced on December 4. Index Ventures led the round, with Greylock, Spark Capital, CRV, and others also participating.

November

• Genspark, an all-in-one AI workspace platform, announced a $275 million Series B round on November 20, valuing the company at $1.25 billion. Investors included Emergence Capital Partners, SBI Investment, and LG Technology Ventures.
• Luma AI, which develops AI models for photo and video creation, raised $900 million in a Series C round, valuing the startup at $4 billion. The round was led by Humain, with participation from Andreessen Horowitz, AMD Ventures, Amplify Partners, and others.
• Viral vibe-coding platform Cursor closed a $2.3 billion funding round announced on November 13. This marked the company’s second round of the year, valuing the business at $29.3 billion.
• Parallel, a company building web infrastructure for AI agents, announced a $100 million Series A round on November 12. The round was co-led by Index Ventures and Kleiner Perkins.
• Healthcare-focused AI agent startup Hippocratic AI raised $126 million in a Series C round announced on November 3. The company was valued at $3.5 billion, and the round — its second of the year — was led by Avenir Growth.

October

• Fireworks AI, a platform that enables developers to build applications using open-source models, announced a $250 million Series C round on October 28, valuing the company at $4 billion.
• Enterprise AI company Uniphore reached a $2.5 billion valuation following a $260 million Series F round announced on October 22. Participants included Snowflake Ventures, Nvidia, Databricks Ventures, AMD, and others.
• Voice AI startup Sesame raised a $250 million Series B round co-led by Sequoia and Spark Capital. The funding was announced on October 21 and also included SignalRank.
• Cambridge, Massachusetts-based OpenEvidence, which develops an AI chatbot for medical professionals, announced a $200 million Series C round on October 20. The round valued the company at $6 billion and marked its second raise of the year.
• Lila Sciences, aiming to build a science superintelligence platform, revealed a $350 million Series A round on October 14. The round was co-led by Braidwell and Collective Global and was the company’s second funding event of 2025.
• Reflection AI, a competitor to DeepSeek, announced its second hefty raise of the year on October 9. The $2 billion Series B round, led by Nvidia, valued the company at $8 billion.
• EvenUp, which applies AI to the personal injury legal sector, disclosed a $150 million Series E round on October 7. The company was valued at more than $2 billion, with Bessemer leading and Lightspeed, Bain Capital, SignalFire, and others participating.

September

• Periodic Labs, a startup working on an AI scientist, announced a $300 million seed round on September 30. Felicis and Andreessen Horowitz led the round, joined by Nvidia, Lightspeed, Khosla Ventures, and others.
• Cerebras Systems raised $1.1 billion in a Series G round, valuing the AI infrastructure company at $8.1 billion. The round was announced on September 30 and co-led by Fidelity and Atreides Management.
• Modular disclosed a $250 million funding round on September 24, led by the US Innovative Technology Fund. GV, Greylock, and General Catalyst also participated.
• Distyl AI, which builds enterprise AI software, announced a $175 million Series B round on September 23. The round valued the company at $1.8 billion and included investors such as Khosla Ventures and Lightspeed.
• Upscale AI, an AI infrastructure startup, raised a $100 million seed round, announced on September 17. The round was co-led by Maverick Silicon and Mayfield, with participation from StepStone Group, Stanford University, Qualcomm Ventures, and others.
• Groq secured $750 million in a Series D-3 round announced on September 17. The funding valued the AI inference company at nearly $6.9 billion and was led by Disruptive.
• Invisible Technologies, an AI training startup, reached a $2 billion valuation after raising $100 million in a round announced on September 16. Vanara Capital led the raise, with Greycroft, Tallwoods Capital, Freestyle Capital, and others participating.
• Cognition AI, the company behind the vibe-coding agent Devin, announced a $400 million Series C round on September 8. The round, led by Founders Fund, valued the company at $10.2 billion.
• Baseten, an AI infrastructure startup, announced a $150 million Series D round on September 5. The round valued the company at $2.1 billion and was led by Bond, with CapitalG, IVP, Spark Capital, and others joining.
• Sierra, Bret Taylor’s customer service AI agent platform, raised $350 million in a round led by Greenoaks Capital. Announced on September 4, the funding valued Sierra at more than $10 billion.
• You.com, a personalised AI search engine, announced a $100 million Series C round on September 3. Cox Enterprises led the round, valuing the company at $1.5 billion.
• Anthropic disclosed its second funding round of 2025 on September 2, announcing a $13 billion Series F raise. The round valued the AI research lab at $183 billion and was led by Iconiq, Fidelity, and Lightspeed.

August

• EliseAI, a healthcare and housing automation platform, raised $250 million in a Series E round announced on August 20. The round, led by Andreessen Horowitz, valued the company at $2.2 billion.
• Decart, an AI research lab, announced a $100 million funding round on August 7 at a $3.1 billion valuation. Participants included Sequoia Capital, Benchmark, Zeev Ventures, and others.

July

• Fal announced a $125 million Series C round on July 31, led by Meritech Capital Partners. The round valued the generative media company at $1.5 billion and included Salesforce Ventures, Shopify Ventures, Google AI Futures Fund, and others.
• Ambience Healthcare, which develops an AI healthcare operating system, raised $243 million in a Series C round. The funding was led by Oak HC/FT and Andreessen Horowitz, with Kleiner Perkins, OpenAI Startup Fund, Smash Capital, and others also participating.
• Reka AI, an AI research lab, secured $110 million in a Series B round announced on July 22. The round included Snowflake and Nvidia and valued the company at $1 billion.
• Thinking Machines Lab confirmed on July 15 that it raised $2 billion in a sizable seed round. Led by Andreessen Horowitz, the round included Nvidia, Accel, AMD, and others, valuing the company at $12 billion.
• OpenEvidence, based in Cambridge, Massachusetts, announced a $210 million Series B round on July 15. The funding valued the AI-powered clinical search startup at $3.5 billion and was led by Kleiner Perkins and GV.
• Harmonic, a startup building a mathematical reasoning engine, raised $100 million in a Series B round announced on July 10. Kleiner Perkins led the round, which valued the company at $875 million.

June

• Abridge, a healthcare AI unicorn, announced a $300 million Series E round, valuing the company at $5.3 billion. The round, announced in June, was led by Andreessen Horowitz with Khosla Ventures also participating, and marked the company’s second raise of the year.
• Legal AI startup Harvey revealed its second $300 million round of 2025 on June 23. This Series E round was co-led by Kleiner Perkins and Coatue and brought the company’s valuation to $5 billion.
• Tennr, a healthcare AI company, raised $101 million in a Series C round led by IVP. Lightspeed Venture Partners, GV, Andreessen Horowitz, and others participated, valuing the company at $605 million.
• Enterprise search startup Glean announced a $150 million Series F round on June 10. Led by Wellington Management, the round included Sequoia, Lightspeed Venture Partners, Kleiner Perkins, and others, and valued the company at $7.25 billion.
• Cursor, an AI coding tool, raised $900 million in a Series C round announced in June. Thrive Capital led the funding, with Andreessen Horowitz, Accel, DST Global, and others participating. The round valued the company at nearly $10 billion.

May

• Snorkel AI, an AI data labelling company, announced a $100 million Series D round on May 29. Led by Addition, the round valued the company at $1.3 billion and included Prosperity7 Ventures, Lightspeed Venture Partners, Greylock, and others.
• LMArena, a community-driven AI model benchmarking platform, announced on May 21 that it raised $100 million in seed funding. The round valued the startup at $600 million and was co-led by Andreessen Horowitz and UC Investments, with Lightspeed Venture Partners, Kleiner Perkins, Felicis, and others also participating.
• TensorWave, an AI infrastructure company based in Las Vegas, announced a $100 million Series A round on May 14. The round was co-led by Magnetar Capital and AMD Ventures and included Prosperity7 Ventures, Nexus Venture Partners, Maverick Silicon, and others.

April

• SandboxAQ closed a $450 million Series E round on April 4, valuing the AI model company at $5.7 billion. Participants included Nvidia, Google, and Bridgewater Associates founder Ray Dalio, among others.
• Runway raised a $308 million Series D rou, nd announced on April 3. The generative media company was valued at $3 billion, with General Atlantic leading and SoftBank, Nvidia, and Fidelity also participating.

March

• OpenAI raised a record-setting $40 billion funding round that closed on March 31. The raise valued the company at $300 billion and was led by SoftBank, with participation from Thrive Capital, Microsoft, Coatue, and others.
• Nexthop AI announced a $110 million Series A round on March 25. Lightspeed Venture Partners led the funding, with Kleiner Perkins, Battery Ventures, Emergent Ventures, and others also participating.
• Insilico Medicine, based in Cambridge, Massachusetts, raised $110 million for its generative AI-powered drug discovery platform in a Series E round announced on March 13. The round valued the company at $1 billion and was co-led by Value Partners and Pudong Chuangtou.
• Celestial AI secured $250 million in a Series C round announced on March 11. The funding valued the AI infrastructure company at $2.5 billion and was led by Fidelity, with participation from Tiger Global, BlackRock, Intel CEO Lip-Bu Tan, and others.
• Lila Sciences announced a $200 million seed round in March as it works toward building a science superintelligence platform. The round was led by Flagship Pioneering and included March Capital, General Catalyst, ARK Venture Fund, and others.
• Brooklyn-based Reflection.AI raised $130 million in a Series A round announced in March. The one-year-old startup, focused on superintelligent autonomous systems, was valued at $580 million, with Lightspeed Venture Partners and CRV leading the round.
• AI coding startup Turing closed a $111 million Series E round on March 7. The funding valued the company at $2.2 billion and was led by Khazanah Nasional, with participation from WestBridge Capital, Gaingels, Sozo Ventures, and others.
• Shield AI, a defence-focused AI company, raised $240 million in a Series F round that closed on March 6. The round was co-led by L3Harris Technologies and Hanwha Aerospace and included Andreessen Horowitz and the US Innovative Technology Fund, valuing the company at $5.3 billion.
• Anthropic announced a $3.5 billion Series E round on March 3. The funding valued the AI research and large language model company at $61.5 billion and was led by Lightspeed, with participation from Salesforce Ventures, Menlo Ventures, General Catalyst, and others.

February

• Together AI raised $305 million in a Series B round announced on February 20. The company, which builds open source generative AI and model development infrastructure, was valued at $3.3 billion. Prosperity7 and General Catalyst co-led the round, with Salesforce Ventures, Nvidia, Lux Capital, and others joining.
• Lambda, an AI infrastructure company, announced a $480 million Series D round on February 19. The funding valued the company at nearly $2.5 billion and was co-led by SGW and Andra Capital, with participation from Nvidia, G Squared, ARK Invest, and others.
• Abridge announced a $250 million Series D round on February 17, valuing the company at $2.75 billion. The round was co-led by IVP and Elad Gil, with participation from Lightspeed, Redpoint, Spark Capital, and others.
• Eudia, a legal AI startup, raised $105 million in a Series A round that closed on February 13. General Catalyst led the round, with Floodgate, Defy Ventures, Everywhere Ventures, and a group of angel investors also participating.
• EnCharge AI, a hardware-focused AI startup based in Santa Clara, closed a $100 million Series B round on February 13. The round was led by Tiger Global and included Scout Ventures, Samsung Ventures, RTX Ventures, and others.
• Harvey announced a $300 million Series D round on February 12, valuing the legal AI company at $3 billion. Sequoia led the round, with OpenAI Startup Fund, Kleiner Perkins, Elad Gil, and others also participating.

January

• ElevenLabs, a synthetic voice startup, raised $180 million in a Series C round announced on January 30. The funding valued the company at more than $3 billion and was co-led by Iconiq and Andreessen Horowitz, with participation from Sequoia, NEA, Salesforce Ventures, and others.
• Hippocratic AI announced a $141 million Series B round on January 9. The funding valued the healthcare-focused AI company at more than $1.6 billion and was led by Kleiner Perkins, with Andreessen Horowitz, Nvidia, General Catalyst, and others also participating.